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地 址:
上海岳阳路320号
邮 编:
200031
电 话:
86-21-54921629
传 真:
86-21-54921333
邮 箱:
klsb@sibcb.ac.cn

 

   

陈洛南

研究员,研究组长,博士生导师
电话:54920100
E-mail: lnchen@sibs.ac.cn
Lab homepage: http://www.sysbio.ac.cn/cb/chenlab/LuonanChen.htm

 

个人简介:

陈洛南1984年获华中科技大学电气工程学士学位;1988年获日本东北大学系统科学硕士学位;1991年获日本东北大学系统科学博士学位。1997年起任日本大阪产业大学副教授;2000年起任美国加州大学洛杉矶分校(UCLA)访问教授;2002年起任日本大阪产业大学教授;2007年筹建上海大学系统生物技术研究所并首任所长(兼);2009年4月起任日本东京大学(兼)研究教授;2009年10月至今任中科院系统生物学重点实验室执行主任,研究员,博士生导师,研究组组长。

研究方向:

生物信息学,网络生物学,计算系统生物学

研究工作:

生物信息学、网络生物学及计算系统生物学等领域的研究工作


代表性论文:

  1. Tao Zeng, Diane Catherine Wang, Xiangdong Wang, Feng Xud, Luonan Chen. Prediction of dynamical drug sensitivity and resistance by module network rewiring-analysis based on transcriptional profiling. Drug Resistance Updates, DOI: 10.1016/j.drup.2014.08.002, 2014.
  2. Andrew E Teschendorff, Xiaoping Liu, Helena Caren, Steve Pollard, Stephan Beck, Martin Widschwendter, Luonan Chen. The dynamics of DNA methylation covariation patterns in carcinogenesis. PLoS Computational Biology, 10(7): e1003709. doi:10.1371/journal.pcbi.1003709, 2014.
  3. Zhenshu Wen, Luonan Chen. MCentridFS: a tool for identifying module biomarkers for multi-phenotypes from high-throughput data. Molecular BioSystems, DOI: 10.1039/C4MB00325J, 2014.
  4. Huanfei Ma, Tianshou Zhou, Kazuyuki Aihara, Luonan Chen. Predicting Time-series from Short-term High-dimensional Data. International Journal of Bifurcation and Chaos, 2014.
  5. Xiaodan Wu, Luonan Chen and Xiangdong Wang. Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases. Clinical and Translational Medicine, 3:16, 2014.
  6. Jiang Xie, Wang Ding, Luonan Chen, Qiang Guo and Wu Zhang. Advances in Protein Contact Map Prediction Based on Machine Learning. Medicinal Chemistry, 2014.
  7. Xiaoru Sun, Minghuan Zheng, Miaomiao Zhang, Mengjia Qian, Yonghua Zheng, Meiyi Li, Dragos Cretoiu, Chengshui Chen, Luonan Chen, Laurentiu M. Popescu and Xiangdong Wang. Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. Journal of Cellular and Molecular Medicine, 2014 May;18(5):801-10. doi: 10.1111/jcmm.12302.
  8. Xiaodan Wu, Luonan Chen and Xiangdong Wang. Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases. Clinical and Translational Medicine 2014, 3:16 doi:10.1186/2001-1326-3-16.
  9. Tao Zeng, Wanwei Zhang, Xiangtian Yu, Xiaoping Liu, Meiyi Li, Rui Liu, Luonan Chen. Edge biomarkers for classification and prediction of phenotypes. SCIENCE CHINA Life Sciences, 2014.
  10. Wanwei Zhang, Tao Zeng, Luonan Chen. EdgeMarker: identifying differentially correlated molecule pairs as edge-biomarkers. Journal of Theoretical Biology, DOI:10.1016/j.jtbi.2014.05.041, 2014.
  11. Rui Liu, Xiangtian Yu , Xiaoping Liu, Dong Xu, Kazuyuki Aihara and Luonan Chen. Identifying critical transitions of complex diseases based on a single sample. Bioinformatics, DOI:10.1093/bioinformatics/btu084, 2014.
  12. B.Liu, Z.Yuan, K.Aihara, L.Chen. Reinitiation enhances reliable transcriptional responses in eukaryotes. J. R. Soc. Interface, 20140326, 2014.
  13. Fang-Xiang Wu, Lin Wu, Jianxin Wang, Juan Liu, Luonan Chen. Transittability of complex networks and its applications to regulatory biomolecular networks. Scientific Reports, DOI: 10.1038/srep04819,2014.
  14. Tao Zeng, Chuan-chao Zhang, Wanwei Zhang, Rui Liu, Juan Liu, Luonan Chen. Deciphering early development of complex diseases by progressive module network. Methods, http://dx.doi.org/10.1016/j.ymeth.2014.01.021, 2014.
  15. Minchao Wang, Wu Zhang, Wang Ding, Dongbo Dai, Huiran Zhang, Hao Xie, Luonan Chen, Yike Guo and Jiang Xie. Parallel Clustering Algorithm for Large-scale Biological Data Sets. PLoS One, 2014.
  16. Doss C. Priya George, Chiranjib Chakraborty, SA Syed Haneef, Nagarajan NagaSundaram, Luonan Chen, Hailong Zhu. Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2). Theranostics, 2014.
  17. Zhang Pengjun, Zou Meng, Wen Xinyu, Gu Feng, Li Juan, Liu Gaixia, Dong Jingxiao, Deng Xinxin, Gao Jing, Li Xiaolong, Jia Xingwang, Dong Zhennan, Chen Luonan,Wang Yong, and Tian Yaping. Development of Serum Parameters Panels for Early Detection of Pancreatic Cancer. International Journal of Cancer, 2014.
  18. Meng Zou, Peng-Jun Zhang, Xin-Yu Wen, Luonan Chen, Ya-Ping Tian and Yong Wang. Identifying multi-biomarkers to distinguish malignant from benign colorectal tumours by a mixed integer programming. Journal of the American Medical Informatics Association, 2014.
  19. Chiranjib Chakraborty, George Priya Doss. C, Luonan Chen, Hailong Zhu. Evaluating protein-protein interaction (PPI) networks using in silico pharmacology: to understand the diseases pathway, target discovery and drug-design. Current Protein and Peptide Science, 2013.
  20. Xiangtan Yu, Guozheng Li, Luonan CHen. Prediction and early diagnosis of complex diseases by edge-network. Bioinformatics, doi:10.1093/bioinformatics/btt620, 2013.
  21. Tao Zeng, Shao-yan Sun, Yong Wang, Hailong Zhu, Luonan Chen. Network biomarkers reveal dysfunctional gene regulations during disease progression. FEBS Journal, doi:10.1111/febs.12536, 2013.
  22. Yong Wang, Xiang-Sun Zhang, Luonan Chen. Computational systems biology in the big data era. BMC Systems Biology, doi:10.1186/1752-0509-7-S2-S1, 2013.
  23. Rui Liu, Xiangdong Wang, Kazuyuki Aihara, Luonan Chen, Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers. Medicinal Research Reviews, DOI:10.1002/med.21293, 2013.
  24. Shao-Yan Sun, Zhi-Ping Liu, Tao Zeng, Yong Wang, and Luonan Chen. Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks. Scientific Reports, DOI: 10.1038/srep02268, 2013.
  25. Jiguang Wang, Yidan Sun, Si Zheng, Xiang-Sun Zhang, Huarong Zhou, and Luonan Chen. APG: an Active Protein-Gene Network Model to Quantify Regulatory Signals in Complex Biological Systems. Scientific Reports, DOI: 10.1038/srep01097, 2013.
  26. Chao Zhang, Jiguang Wang, Kristina Hanspers, Dong Xu, Luonan Chen, Xiang-Sun Zhang, Alexander R. Pico. NOA: A Cytoscape Plugin for Network Ontology Analysis. Bioinformatics, 2013.
  27. Xiaoping Liu, Xiaodong Zhang, Wei-Hua Tang, Luonan Chen and Xing-Ming Zhao. eFG: an electronic resource for Fusarium graminearum. Database, doi:10.1093/database/bat042, 2013.
  28. Mingzhu Zhao, Hao-Teng Chang, Zhiping Liu, Luonan Chen, Dongqing Wei. Predicting Protein--Ligand Interactions Based on Chemical Preference Features with its Application to New D--Amino Acid Oxidase Inhibitor Discovery. Current Pharmaceutical Design, 2013.
  29. Jiang Xie, Zhonghua Zhou, Kai Lu, Luonan Chen, Wu Zhang. Visualization of Biomolecular Networks Comparison on Cytoscape. Tsinghua Science and Technology, 2013.
  30. Zikai Wu, Yong Wang, Luonan Chen. A New Framework for Drug Repositioning by Incorporating Functional Information. IET Systems Biology, 2013.
  31. Meiyi Li, Tao Zeng, Yong Wang, Luonan Chen. Detecting tissue-specific early-warning signals for complex diseases based on dynamical network biomarkers: study of type-2 diabetes by cross-tissue analysis. Briefings in Bioinformatics, 2013.
  32. Rui Liu, Kazuyuki Aihara, Luonan Chen. Dynamical network biomarkers for identifying critical transitions of biological processes. Quantitative Biology, DOI 10.1007/s40484-013-0008-0, 2013.
  33. Songyot Nakariyakul, Zhi-Ping Liu, Luonan Chen. A Sequence-based Computational Approach to Predicting PDZ Domain-Peptide Interactions. BBA - Proteins and Proteomics, 2013.
  34. Zikai Wu, Yong Wang, Luonan Chen. Network-Based Drug Repositioning. Molecular BioSystems, DOI:10.1039/C3MB25382A, 2013.
  35. Chenglei Sun, Zheng-Zheng Shi, Xiaobo Zhou, Luonan Chen, Xing-Ming Zhao. Prediction of S-Glutathionylation Sites Based on Protein Sequences. PLoS ONE 8(2): e55512. doi:10.1371/journal.pone.0055512, 2013.
  36. George Priya Doss C, Nagasundaram N, Chiranjib Chakraborty, Luonan Chen and Hailong Zhu. Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: A Molecular dynamics approach, Human Genomics, 2013.
  37. Zhiyuan Yang, Yan Zhang, and Luonan Chen. Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat. BMC Systems Biology, 2013.
  38. Zhi-Ping Liu, Wanwei Zhang, Katsuhisa Horimoto, and Luonan Chen. A Gaussian Graphical Model for Identifying Significantly Responsive Regulatory Networks from Time Course High-Throughput Data. IET Systems Biology, 2013.
  39. Peipei Zhou, Shuiming Cai, Zengrong Liu, Luonan Chen, Ruiqi Wang. Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems. Chaos, Solitons & Fractals, 7242, 2013.

 

 
   
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